Losartan News
Angiotensin II activates myostatin expression in cultured rat neonatal cardiomyocytes via p38 MAP kinase and MEF-2 pathway
Angiotensin II (AngII) plays a critical role in cardiac remodeling and promotes cardiac myocyte hypertrophy.
High Serum Uric Acid Linked to Increased Mortality Due to CHF and Stroke
Traditionally, elevated serum uric acid (SUA) is linked to gout. Recent investigations have shown that there may be a relationship between hyperuricemia and ischemic heart disease and metabolic syndrome, which is characterized by...
Angiotensin type-1 receptor blockade with losartan increases insulin sensitivity and improves glucose homeostasis in subjects with type 2 diabetes and nephropathy
Background. A growing body of evidence supports the concept that treatment with the newer angiotensin type-1 receptor blockers (ARBs) improves glucose homeostasis under conditions wherein it is impaired. Controversy exists,...
Common Blood Pressure Drug Treats Muscular Dystrophy in Mice
Researchers at Johns Hopkins have shown that a drug commonly used to lower blood pressure reverses muscle wasting in genetically engineered mice with Marfan syndrome and also prevents muscle degeneration in mice with Duchenne...
Renal Allograft Protection with Angiotensin II Type 1 Receptor Antagonists
The renal benefits of agents inhibiting the renin-angiotensin-aldosterone system in renal transplant recipients, i.e. preventing the development of chronic graft nephropathy, are supposed but not finally proven.